Functional Sensitivity and Recovery of Thyroid-stimulating Hormone

Functional sensitivity and recovery of thyroid-stimulating hormone.

To the Editor: Comparisons of the Vitros ECi thyroid-stimulating hormone (TSH) method with the AxSym (1 ), Immulite (1, 2), Elecsys (2 ), and ADVIA Centaur (2 ) have shown an unexplained progressive negative bias ,0.2 mIU/L, a phenomenon that we have also observed (Fig. 1A). To investigate the bias, we diluted the TSH International Reference Preparation 80/558 (predominately pituitary TSH) and ...

Thyroid Stimulating Hormone Thyroid Stimulating Hormone

Thyroid Stimulating Hormone Receptor

Thyroid stimulating hormone receptor (TSHR) plays a pivotal role in thyroid hormone metabolism. It is a major controller of thyroid cell function and growth. Mutations in TSHR may lead to several thyroid diseases, most commonly hyperthyroidism. Although its genetic and epigenetic alterations do not directly lead to carcinogenesis, it has a crucial role in tumor growth, which is initiated by sev...

Goitrogenic Anions, Thyroid-Stimulating Hormone, and Thyroid Hormone in Infants

BACKGROUND Environmental exposure of infants to perchlorate, thiocyanate, nitrate, might interfere with thyroid function. U.S. women with higher background perchlorate exposure have higher thyroid-stimulating hormone (TSH) and lower thyroxine (T4). There are no studies with individual measures of thyroid function and these goitrogens available in infants. OBJECTIVE We examined the association...

Human melanoma cells express functional receptors for thyroid-stimulating hormone.

We have reported a high prevalence of hypothyroidism in the cutaneous melanoma population, suggesting that the pathologic hormonal environment of hypothyroidism promotes melanoma growth. The objective of this study was to test the hypothesis that TSH, which circulates at elevated levels in hypothyroid individuals, stimulates the growth of melanoma cells. Our results show that TSH receptors (TSH...